Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 23 11 2020 11 01 COVID-19 and Digestive System in Children: A Retrospective Study 782 786 10.34172/aim.2020.104 EN Mohammadreza Esmaeili Dooki https://orcid.org/0000-0002-0815-4499 Sanaz Mehrabani https://orcid.org/0000-0002-2062-0448 Hadi Sorkhi Maryam Nikpour Mohamadreza Tabatabaie Mohsen Mohammadi Masood Kiani Journal Article 10.34172/aim.2020.104 2020 06 07 2020 09 06 Background: The aim of this study was to identify gastrointestinal (GI) and liver injury presentations in children admitted with COVID-19 infection. Methods: In this retrospective study, we studied all children with suspected symptoms of COVID-19, referred to Amirkola Children’s Hospital. Clinical manifestations of the digestive and respiratory systems and liver function tests were evaluated for all cases. Results: Eighteen children were studied. The most common clinical symptoms were fever, anorexia, weakness, nausea and vomiting, cough, diarrhea, and abdominal pain, respectively. Also, 5/18 (27.8%) and 7/18 (38.9%) of cases had abnormally high alanine aminotransferase (ALT), aspartate aminotransferase (AST), respectively. Additionally, in icteric cases, direct bilirubin was raised. There was no significant relationship between pulmonary lesions and abnormal excess in ALT (P = 0.59) and AST (P = 0.62). Conclusion: The findings showed that there were no severe clinical GI symptoms in children with COVID-19 infection. Besides, children with increased liver enzymes did not have more respiratory involvement than those without a rise in liver enzymes.