Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 24 9 2021 09 01 Relapse of Lymphangioleiomyomatosis Five Years after Bilateral-Lung Transplantation 701 703 10.34172/aim.2021.101 EN Jalal Heshmatnia https://orcid.org/0000-0003-2966-4380 Maryam Sadat Mirenayat https://orcid.org/0000-0002-0852-1666 Mitrasadat Rezaei https://orcid.org/0000-0002-7242-5839 Felix Bongomin https://orcid.org/0000-0003-4515-8517 Mehrdad Bakhshayeshkaram Payam Tabarsi Kambiz Sheikhy https://orcid.org/0000-0003-3565-9801 Vida Mortezaee https://orcid.org/0000-0003-0623-2307 Journal Article 10.34172/aim.2021.101 2020 11 29 2021 03 15 Pulmonary lymphangioleiomyomatosis (LAM) is an uncommon disease principally affecting women during childbearing years and eventually leading to progressive respiratory failure. Lung transplantation is a viable option for patients with end-stage disease. LAM-related complications remain common, but recurrence of LAM following allograft transplantation is rare. We present a 25-year-old woman who presented with progressive dyspnea five years after bilateral lung transplantation for end-stage LAM. Histological examination of transbronchial lung biopsy sample confirmed recurrent LAM. We changed cyclosporine to sirolimus and she is currently being considered for re-transplantation.