Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 25 6 2022 06 01 Sunitinib-Induced Congestive Heart Failure in a Patient with Gastrointestinal Stromal Tumor 399 401 10.34172/aim.2022.64 EN Wala Ben Kridis https://orcid.org/0000-0002-4956-9551 Sonda Masmoudi Salma Ben Charfeddine Afef Khanfir Journal Article 10.34172/aim.2022.64 2021 04 20 2021 05 05 Common cardiovascular toxicities of sunitinib mainly include hypertension, QT prolongation, left ventricular dysfunction (LVD) and less frequently, congestive heart failure (CHF). Here, we report the case of a 67-year-old woman who developed heart failure after 24 months of sunitinib. Our case highlights the importance of strict and regular cardiovascular monitoring during sunitinib. It also shows that the reintroduction of sunitinib with maintaining heart failure treatment can be safe. The exact mechanisms of this cardiotoxicity have not been understood. There is no protective therapy available. Therefore, further investigations are needed in these areas. Medical specialists who prescribe and treat patients with sunitinib should be aware of the possible occurrence of these conditions and perform regular checkup of sunitinib-treated patients.