Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 26 12 2023 12 01 Mixed Hepatocellular–Neuroendocrine Carcinoma: A Case Report and Literature Review 709 711 10.34172/aim.2023.104 EN wala Ben Kridis https://orcid.org/0000-0002-4956-9551 ahmed jribi Rim Kallel Tahia Boudawara Afef Khanfir Journal Article 10.34172/aim.2023.104 2023 02 27 2023 07 03 Mixed hepatocellular-neuroendocrine carcinoma (HCC-NEC) is a rare entity with a poor prognosis. We report a case of a 44-yearold Tunisian man who was admitted for diffuse abdominal pain. Body computed tomography showed multinodular hepatomegaly. Pathologic findings concluded to HCC-NEC. Clinicians should be aware about this entity. Further collection of case reports is needed to standardize the optimal treatment.