Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 27 12 2024 12 01 Urgent Alert: Potential Risk of Dengue Infection Transmission Through Blood Transfusion in Iran 693 699 10.34172/aim.31756 EN Zahra Taghinejad https://orcid.org/0000-0001-7373-6092 Mohammad Asgharzadeh https://orcid.org/0000-0003-3386-4342 Ali Akbar Pourfathollah https://orcid.org/0000-0002-1814-0875 REVIEW 10.34172/aim.31756 2024 07 22 2024 10 13 Dengue infection is an emerging public health issue in Iran, with about 149 confirmed newly infected cases. It can be transmitted by the bite of infected Aedes mosquitoes and even nosocomial routes. Due to the rapid replication and geographical spread of the mosquito, there is a potential risk of increased infected individuals. Given the possibility of the transmission of dengue infection through transfusion, it is important to implement policies to improve blood safety. Proper donor selection by utilizing appropriate blood donor questionnaires and performing general physical examinations, along with performing sensitive diagnostic tests on blood donor samples, utilizing pathogen reduction techniques, and implementing lookback programs, can be effective in reducing the risk of transfusion-transmitted dengue virus (TT-DENV).