Academy of Medical Sciences of I.R. Iran Archives of Iranian Medicine 1029-2977 28 5 2025 05 01 Burden of Tracheal, Bronchus, and Lung Cancer Attributable to High Fasting Plasma Glucose 286 295 10.34172/aim.33332 EN Jingyi Zhou https://orcid.org/0009-0009-4726-9684 Chenglong Xi https://orcid.org/0009-0008-6820-2959 Zhiyu Luan https://orcid.org/0009-0004-8182-8703 Lufeng Mao https://orcid.org/0009-0008-7981-4192 Shiliang Ling https://orcid.org/0000-0002-5755-7622 Journal Article 10.34172/aim.33332 2024 10 27 2025 03 11 Background: We aimed to evaluate the situation and change trends in the tracheal, bronchus, and lung (TBL) cancer burden attributable to high fasting plasma glucose (HFPG) stratified by gender, age, region, country, and sociodemographic index (SDI). Methods: We evaluated the age-standardized death rate (ASDR) and disability-adjusted life years (DALYs) rate of TBL cancer attributable to HFPG and their corresponding estimated annual percentage change (EAPC) trends in 204 countries and 21 regions. Results: Globally from 1990 to 2019, the ASDR (EAPC=0.98; 95% confidence interval [CI]: 0.82–1.15) and age-standardized DALY rate (EAPC=0.68; 95% CI: 0.55–0.82) of TBL cancer attributable to HFPG trended upward. Furthermore, the steepest increment in age-standardized death and DALY rates were noted in low-SDI regions (EAPC=1.32; EAPC=1.35) and the North Africa/Middle East region (EAPC=2.66, ESPC=2.56) among all five SDI regions and 21 global geographic regions, respectively. Among the 204 countries, the highest growth rate in the ASDR was found in Georgia (EAPC=4.33, 95% CI: 3.66–5.00), and the highest growth rate in the age-standardized DALY rate occurred in Egypt (EAPC=4.34, 95% CI: 4.22–4.47). The highest ASDR and age-standardized DALY rate occurred in people over the age of 65 years, and in the 21 geographic regions, SDIs were negatively correlated with ASDRs and EAPCs in DALYs. Conclusion: The global burden of TBL cancer attributable to HFPG trended upward. The most significant increase in burden was observed in low-SDI regions and countries.